After some background information on what redox state means for exercise and your mitochondria, we look at some experiments linking various intensities of exercise to adaptations. Then we look at where these signals overlap with dieting and rest, and tie these into advice and realistic expectations for training, recovery, and nutrition. We also answer your listener questions on RED-S, measuring recovery, exercise intensity, and more.
Review papers on fluorescence measurement and redox adaptations
Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies
NAD+/NADH and skeletal muscle mitochondrial adaptations to exercise
Main podcast study
Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle
Frequently referenced study linking SIRT activation to mitochondrial biogenesis (not mentioned in episode)
Sirtuin 1 (SIRT1) Deacetylase Activity Is Not Required for Mitochondrial Biogenesis or Peroxisome Proliferator-activated Receptor-γ Coactivator-1α (PGC-1α) Deacetylation following Endurance Exercise*