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This episode explores how and why hemoglobin's function emerges from its structure, which makes it a critical component in the oxygen distribution chain. We also discuss the lungs, why VO2max isn't related to hematocrit, and vascular capacity for blood storage before diving into a classic phlebotomy study that ends with a question mark that hints at the central importance of the heart.
Show Notes Blood value correlations with vo2max, Figure 1 https://pubmed.ncbi.nlm.nih.gov/30549016/ Effects of detraining on cardiovascular responses to exercise: role of blood volume https://journals.physiology.org/doi/pdf/10.1152/jappl.1986.60.1.95 
Hemoglobin dissociation curve with right (Bohr) and left (Haldane) shifts.
Myoglobin vs hemoglobin O2 binding curves with approximate arterial and venous O2 pressures. Image courtesy of Robert Prince.
1 Comment
8/12/2020 02:58:38 pm
Just to add one more factor to the first table: Hemoglobin A1c (glycosylated hemoglobin) also has a left-shifted dissociation curve. Thus, with diabetes mellitus, as Hb A1c concentration increases with poor blood glucose control, the hemogolbin dissociation curve is shifted somewhat to the left. Your comment will be posted after it is approved.
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